C. Liao

Micron-resolution fiber mapping in histology independent of sample preparation

This paper introduces ComSLI, a method to map fiber networks in histology without sample preparation, showing its application across tissues and diseases.

A type II secreted subtilase from commensal rhizobacteria disarms the immune elicitor peptide flg22

The paper identifies a type II secreted subtilase from commensal bacteria that cleaves the immune elicitor flg22, suppressing plant immune responses.

Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

The paper identifies three tobacco-derived compounds with neuroprotective effects against Alzheimer's disease using a genetic engineering approach with neural progenitor cells.

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and Susceptibility imaging

This paper introduces sEPTI, a 3D imaging technique for rapid whole-brain T2* and susceptibility mapping, achieving faster imaging and improved quality compared to existing methods.

In situ structural insights into the excitation contraction coupling mechanism of skeletal muscle

This study reveals the nanometre-resolution structure of the RyR1-DHPR supercomplex in skeletal muscle triads, showing their unique arrangement and physical coupling mechanism for excitation-contraction coupling.

Reply to: Contribution of carbon inputs to soil carbon accumulation cannot be neglected

The paper responds to a critique that carbon inputs were neglected in a study on soil carbon storage, arguing that empirical data do not support the critique and that further research is needed.

A CRISPR-based genetic screen in Bacteroides thetaiotaomicron reveals a small RNA modulator of bile susceptibility

The paper uses CRISPRi in Bacteroides thetaiotaomicron to identify a small RNA that modulates bile salt susceptibility.

Fitness and transcriptomic analysis of pathogenic Vibrio parahaemolyticus in seawater at different shellfish harvesting temperatures

This study compares the growth and transcriptomic responses of two Vibrio parahaemolyticus strains with different virulence genes at varying temperatures, showing differential growth rates and gene expression patterns.

A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health

The paper investigates the association between oral bacteria in feces and gut microbiota depletion, supporting the Marker hypothesis over the Expansion hypothesis.

The TaxUMAP atlas: efficient display of large clinical microbiome data reveals ecological competition involved in protection against bacteremia

The paper introduces TaxUMAP, a visualization tool for microbiome data, revealing that Klebsiella species reduce bacteremia risk through competition with other pathogens.

Alignment-free microbiome-based classification of fresh produce safety and quality

This study compares alignment-free k-mer hash and ASV methods for classifying fresh produce safety and quality using microbiome data, finding higher accuracy with k-mer hashes.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

This study shows that inhibiting ABL1 kinase reduces genomic instability and enhances the efficacy of chemotherapy in multiple myeloma.

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor

This study identifies APE1 as a driver of genomic instability in solid tumors, showing its role in chemoresistance and tumorigenesis through effects on DNA repair and genome stability.

Ecological dynamics of the gut microbiome in response to dietary fiber

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

Rapid simultaneous acquisition of macromolecular tissue volume, susceptibility, and relaxometry maps

This paper develops a method to rapidly acquire multiple MRI maps by combining contrasts and reducing scan time using JVC-GRAPPA, achieving 6-minute scans with isotropic resolution.

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

Reduced virulence and enhanced host adaption during antibiotics therapy: A story of a within-host carbapenem-resistant Klebsiella pneumoniae sequence type 11 evolution in a fatal scrotal abscess patient

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.

Divergent use of metabolic fluxes in breast cancer metastasis

This study identifies a strong Warburg effect in lung-homing breast cancer cells, characterized by high lactate secretion and a specific gene expression signature, which correlates with lung metastases.

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinoma

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.

Molecular Basis for the Adaptive Evolution of Environment Sensing by H-NS Proteins

This study investigates how H-NS proteins evolved to sense environmental changes by comparing orthologs from different bacteria and using biophysical methods to reveal electrostatic interactions involved in adaptation.

Modeling microbial cross-feeding at intermediate scale portrays community dynamics and species coexistence

The paper develops an intermediate-scale model to describe microbial cross-feeding interactions, showing it accurately captures community dynamics and species coexistence in experimental data.

From SARS-CoV to Wuhan 2019-nCoV Outbreak: Similarity of Early Epidemic and Prediction of Future Trends

The paper was withdrawn due to lack of full author consent and is not intended for citation.

Enhanced inference of ecological networks by parameterizing ensembles of population dynamics models constrained with prior knowledge

The paper improves ecological network inference by combining prior knowledge with an ensemble of population dynamics models, showing strong interactions and future trends in a freshwater fish community.