Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells
Y. Harada, Y. Mizote, T. Suzuki, M. Nishida, T. Hiratsuka, A. Ueda, Y. Imagawa, K. Maeda, Y. Ohkawa, J. Murai, H. H. Freeze, E. Miyoshi, S. Higashiyama, H. Udono, N. Dohmae, , N. Taniguchi
This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.
bioRxiv · Oct 17, 2022Cancer Biology