H. Pertinez

Hyaluronidase impacts exposures of long-acting injectable paliperidone palmitate in rodent models

This study evaluates how hyaluronidase affects the release and pharmacokinetics of a long-acting injectable drug in mice and rats.

Using dynamic oral dosing of rifapentine and rifabutin to simulate exposure profiles of long-acting formulations in a mouse model of tuberculosis preventive therapy

Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.

This paper investigates probenecid's antiviral activity against SARS-CoV-2 in Vero E6 cells and Syrian golden hamsters, finding no significant inhibition of viral replication or cytopathic effects.

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

This study evaluates Ronapreve's efficacy against SARS-CoV-2 Delta and Omicron variants in mice, showing reduced viral burden and altered pulmonary response for Delta but not Omicron.

Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters

This study evaluates intranasal nafamostat and camostat for preventing SARS-CoV-2 infection in Syrian golden hamsters, finding nafamostat effective in keeping viral RNA undetectable for 7 days.

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.

The paper describes an LC-MS/MS assay validated for quantifying tizoxanide in human plasma, mouse plasma, and DMEM with FBS, showing high accuracy and precision.

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir.

This paper develops a sensitive LC-MS/MS assay for quantifying favipiravir, showing high accuracy and precision across a wide concentration range.

Optimisation and validation of a sensitive bioanalytical method for niclosamide.

The paper develops and validates a sensitive LC-MS/MS assay for niclosamide to study its pharmacokinetics and potential use in preclinical and clinical evaluations.