Author

H. Cox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. Borrell· 3 shared S. Gagneux· 3 shared D. Brites· 2 shared A. Abimiku· 1 shared A. Al Shihabi· 1 shared A. Avihingsanon· 1 shared A. Davarifar· 1 shared A. Enrique-Gonzalez· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersEvolutionary Biology

S. Borrell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa

E. M. Windels, E. M. Wampande, M. L. Joloba, W. H. Boom, G. A. Goig, H. Cox, J. Hella, S. Borrell, S. Gagneux, D. Brites, T. Stadler

This study uses genomic data and a Bayesian phylodynamic model to show HIV co-infection reduces Mycobacterium tuberculosis transmissibility in sub-Saharan Africa.

bioRxiv · Sep 12, 2023Microbiology

The landscape of drug sensitivity and resistance in sarcoma

A. Al Shihabi, P. J. Tebon, H. T. L. Nguyen, J. Chantharasamee, S. Sartini, A. Davarifar, A. Y. Jensen, M. Diaz-Infante, H. Cox, A. Enrique-Gonzalez, S. Swearingen, N. Tavanaie, S. Dry, A. Singh, B. Chmielowski, , A. Soragni

This study uses patient-derived tumor organoids to identify drug sensitivity and resistance patterns in sarcoma, finding actionable treatment regimens for 59% of tested specimens.

bioRxiv · May 25, 2023Cancer Biology

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

L. Tatham, A. Kipar, J. Sharp, E. Kijak, J. Herriott, M. Neary, H. Box, E. Gallardo Toledo, A. Valentijn, H. Cox, H. Pertinez, P. Curley, U. Arshad, R. K. Rajoli, S. Rannard, , A. Owen

This study evaluates Ronapreve's efficacy against SARS-CoV-2 Delta and Omicron variants in mice, showing reduced viral burden and altered pulmonary response for Delta but not Omicron.

bioRxiv · Jan 23, 2022Microbiology

HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis

C. Loiseau, D. Brites, M. Reinhard, K. Zuercher, S. Borrell, M. Ballif, L. Fenner, H. Cox, L. K. Rutaihwa, R. J. Wilkinson, M. Yotebieng, E. J. Carter, A. Abimiku, O. Marcy, E. Gotuzzo, , S. Gagneux

The paper analyzes drug-resistant Mtb genomes from HIV coinfected and HIV negative patients, finding that HIV coinfected patients have more low fitness rpoB variants in rifampicin-resistant strains.

bioRxiv · Jul 20, 2020Evolutionary Biology

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

M. Merker, M. Barbier, H. Cox, J.-P. Rasigade, S. Feuerriegel, T. A. Kohl, R. Diel, S. Borrell, S. Gagneux, V. Nikolayevskyy, S. Andres, U. Nübel, P. Supply, T. Wirth, S. Niemann

The paper investigates the evolutionary mechanisms behind multidrug-resistant tuberculosis in Central Asia, finding that compensatory mutations enhance resistance and transmission success.

bioRxiv · May 31, 2018Evolutionary Biology