Cancer BiologybioRxiv
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.
H. L. Mackay, H. R. Stone, K. Ellis…·J. R. Morris
This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.
DOI 10.1038/s41467-024-52250-4