Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells
O. Matthews, E. E. Morrison, J. D. Tranter, P. Starkey Lewis, I. Toor, A. Srivastava, R. Sargeant, H. Rollison, K. P. Matchett, G. A. Gray, C. Goldring, K. Park, L. Denby, N. Dhaun, M. A. Bailey, , J. W. Dear
This study shows that hepatocyte-derived microRNA, particularly miR-122, is transferred to kidney tubular cells and regulates CYP2E1 expression, influencing drug toxicity.
bioRxiv · Jan 6, 2020Pharmacology & Toxicology