ImmunologybioRxiv
Reverse engineering of a pathogenic antibody reveals the molecular mechanism of vaccine-induced immune thrombotic thrombocytopenia
D. G. Ivanov, N. Ivetic, Y. Du…·I. A. Kaltashov
This paper identifies a pathogenic antibody causing VITT, characterizes its structure and function, and reveals the molecular mechanism involving electrostatic interactions and immune complex formation.
DOI 10.1021/jacs.3c07846