Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase
G. Zenkeviciute, W. Xu, J. Iegre, H. Seki, Y. S. Tan, P. J. Rowling, F. Ferrer, C. S. Verma, D. Spring, H. Laman, L. Itzhaki
This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.
bioRxiv · Apr 27, 2023 · PreprintCancer Biology