Author

P. J. Rowling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. A. Vinogradov· 1 shared C. S. Verma· 1 shared D. B. Ascher· 1 shared D. Spring· 1 shared F. Ferrer· 1 shared G. Kelly· 1 shared G. Zenkeviciute· 1 shared H. Laman· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. A. Vinogradov

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2 papers

Recent·Most cited

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

H. R. King, M. Bycroft, T.-B. Nguyen, G. Kelly, A. A. Vinogradov, P. J. Rowling, K. Stott, D. B. Ascher, H. Suga, L. S. Itzhaki, K. Artavanis-Tsakonas

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.

bioRxiv · Jan 11, 2024 · PreprintBiophysics

Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase

G. Zenkeviciute, W. Xu, J. Iegre, H. Seki, Y. S. Tan, P. J. Rowling, F. Ferrer, C. S. Verma, D. Spring, H. Laman, L. Itzhaki

This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.

bioRxiv · Apr 27, 2023 · PreprintCancer Biology