Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase
G. Zenkeviciute, W. Xu, J. Iegre…·L. Itzhaki
This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.