Author

D. Spring

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Ferrer· 2 shared C. Lindon· 1 shared C. Okoye· 1 shared C. Phillips· 1 shared C. S. Verma· 1 shared C. Stubbs· 1 shared D. Barford· 1 shared E. J. Fisher· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

F. Ferrer

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

R. Eapen, C. Okoye, C. Stubbs, M. Schimpl, T. Tischer, E. J. Fisher, M. Zacharopoulou, F. Ferrer, D. Barford, D. Spring, C. Lindon, C. Phillips, L. S. Itzhaki

This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.

bioRxiv · Apr 30, 2024Biochemistry

Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase

G. Zenkeviciute, W. Xu, J. Iegre, H. Seki, Y. S. Tan, P. J. Rowling, F. Ferrer, C. S. Verma, D. Spring, H. Laman, L. Itzhaki

This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.

bioRxiv · Apr 27, 2023 · PreprintCancer Biology