Author

H. Witwit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

J. C. de la Torre· 3 shared B. Cubitt· 2 shared A. Bukreyev· 1 shared A. Kim· 1 shared A. Salaniwal· 1 shared A. Y. Ting· 1 shared C. Pietzsch· 1 shared C. Ye· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

J. C. de la Torre

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Author profile →

3 papers

Recent·Most cited

Activation of Protein Kinase R (PKR) Plays a Pro-Viral Role in Mammarenavirus Infected Cells

H. Witwit, R. Khafaji, A. Salaniwal, A. Kim, B. Cubitt, C. Ye, N. Jackson, S. R. Weiss, L. Martinez-Sobrido, J. C. de la Torre

This study shows that PKR activation can both restrict and enhance LCMV replication, revealing a complex role for PKR in mammarenavirus infection.

bioRxiv · Dec 5, 2023Microbiology

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.

J. Fang, C. Pietzsch, H. Witwit, G. Tsaprailis, G. Crynen, K. F. Cho, A. Y. Ting, A. Bukreyev, E. O. Saphire, J. C. de la Torre

The paper identifies eRF3a/GSPT1 as a druggable host target for antiviral therapy against Lassa virus by analyzing its interactome using proximity proteomics.

Proceedings of the National Academy of Sciences · Jul 18, 2022Peer-reviewedMicrobiology

Inhibitors of anti-apoptotic Bcl-2 family proteins exhibit potent and broad-spectrum anti-mammarenavirus activity via cell cycle arrest at G0/G1 phase

Y.-J. Kim, H. Witwit, B. Cubitt, J. C. de la Torre

This paper shows Bcl-2 inhibitors like ABT-737 and OLX block mammarenavirus and SARS-CoV-2 by causing G0/G1 cell cycle arrest, not through apoptosis.

bioRxiv · Aug 16, 2021Microbiology