Haiwei Gu

The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice

This study shows that S-equol, a microbial metabolite, reduces cadmium-induced neurotoxicity in mice by restoring neural gene expression and is associated with lower levels in humans carrying the apolipoprotein E4 allele.

Mechanosignaling Promotes Macrophage Apoptosis Resistance in Pulmonary Fibrosis via Metabolic Reprogramming

This study shows that mechanical stiffness in fibrotic lungs promotes macrophage apoptosis resistance through metabolic reprogramming, contributing to fibrosis progression.

Akkermansia muciniphila prevents cadmium-induced cognitive impairment through gut microbiome mediated mechanisms

This study shows that Akkermansia muciniphila prevents cadmium-induced cognitive impairment in mice through gut microbiome and metabolite mechanisms, not by reducing brain cadmium levels.

Amino Acid-Stimulated Muscle Protein Synthesis is Attenuated During Early Recovery from Aerobic Exercise in Individuals with Obesity

Relief of allosteric inhibition, redox imbalance, and transport limitations enables high-yield L-malate production in Escherichia coli

This study improves an Escherichia coli strain for high-yield L-malate production by modifying allosteric regulation, redox balance, and transport, achieving a mass yield of 1.2 g malate per gram of glucose.

Proteome-wide reverse molecular docking reveals folic acid receptor as a mediator of PFAS-induced neurodevelopmental toxicity

This study identifies folic acid receptor beta as a mediator of PFAS-induced neurodevelopmental toxicity using zebrafish models and reverse molecular docking.

Untargeted metabolomic profiling reveals mTORC1-dependent regulation of amino acid utilization in lymphatic endothelial cells

The paper uses untargeted metabolomic profiling to show that mTORC1 regulates amino acid utilization in lymphatic endothelial cells, affecting glutaminolysis and branched-chain amino acid metabolism.

O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells

This study shows that O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells by linking dietary metabolism to transcriptional control.

Erythropoietin Mediates Glycerophospholipid Remodeling During Human Early Erythropoiesis

This study identifies erythropoietin's role in regulating glycerophospholipid metabolism during human erythropoiesis using single-cell transcriptomics and lipidomics.

Glucose and Oxygen Metabolism Coordinate Human Cortical Developmental Decisions

This study shows that physiologic glucose and oxygen levels influence human cortical development by altering metabolic states and cell fate decisions in organoids.

In vivo exposure of mixed microplastic particles in mice and its impacts on the murine gut microbiome and metabolome

This study shows that microplastic exposure alters gut microbiome composition and serum metabolome in mice, with sex-specific and dose-dependent effects.

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

The paper shows that butyrate rescues CPF-induced social deficits in zebrafish by inhibiting class I HDACs, linking CPF exposure to gut microbiome, metabolome, and epigenetic changes.

Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice

This study shows Cd exposure causes gut dysbiosis before cognitive deficits in mice, with altered gut microbiota linked to hippocampus-dependent memory impairments.

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

The paper identifies FABP4/5 as key regulators of endothelial glycolysis and arterial programming in pulmonary hypertension using single-cell and spatial transcriptomics.

Exercise Conditioning Enhances Insulin Sensitivity with Metabolic and Glycemic Control Driven by Hepatic Silencing of HMGB1 in Type 2 Diabetic Mice

This study shows that exercise improves insulin sensitivity in T2D mice by reducing HMGB1 levels in the liver, leading to better glycemic control and metabolic health.

Maternal dietary deficiencies in folic acid and choline change metabolites levels in offspring after ischemic stroke

This study examines how maternal dietary deficiencies in folic acid and choline affect offspring metabolite levels after ischemic stroke, showing sex-specific differences.

Unlocking the Potential: FKK6 as a Microbial Mimicry Based Therapy for Chronic Inflammation-Associated Colorectal Cancer in a Murine Model

This study evaluates FKK6, a microbial mimic of an indole metabolite, as a therapy for colitis-associated colorectal cancer in mice, showing anti-tumor effects and safety.

Joint exome and metabolome analysis in individuals with dyslexia: Evidence for associated dysregulations of olfactory perception and autoimmune functions

This study analyzes exome and metabolome data from individuals with dyslexia to identify associated dysregulations in olfactory perception and immune functions.

A data-fusion approach to identifying developmental dyslexia from multi-omics datasets

This study uses data fusion and machine learning to analyze multi-omics and clinical data, finding that ensemble methods outperform traditional techniques in identifying developmental dyslexia with high accuracy.

An aging clock using metabolomic CSF

This paper develops a metabolomic age prediction model using CSF data from healthy humans and applies it to Alzheimer's and Parkinson's patients, finding increased prediction error in disease cohorts.

MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

This paper shows MLX and MondoA are essential for male fertility and tumor survival, with MLX regulating metabolism, stress, and germ cell development.