Cell BiologybioRxivPreprint
Linked regulation of genome integrity and senescence-associated inflammation by p53
Karl N. Miller, Brightany Li, Hannah R. Pierce-Hoffman…·Peter D. Adams
This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.
DOI 10.1101/2023.11.20.567963