Author
The Netherlands Cancer Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
Lise Dauban, M Eder, Marcel de Haas…·Bas van Steensel
The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.
Ning Qing Liu, Mikhail D. Magnitov, Marijne M. G. A. Schijns…·Elzo de Wit
This study shows that cohesin accumulates at CTCF-bound loop anchors after WAPL depletion, and active genes form long-range clusters independent of cohesin.
Mikhail D. Magnitov, Michela Maresca, Noemí Alonso Saiz…·Elzo de Wit
This study shows ZNF143 regulates nuclear-encoded mitochondrial genes and is essential for development, without affecting chromatin looping or CTCF interactions.
Anna G. Manjón, Stefano Giustino Manzo, Stefan Preković…·René H. Medema
The paper shows that disrupting nuclear lamina association promotes ABCB1 gene derepression and taxol resistance in RPE cells.
Michela Maresca, Teun van den Brand, Hangpeng Li…·Elzo de Wit
The paper identifies that SOX2 maintains chromatin accessibility at regulatory sites that drive gene expression, distinguishing them from non-activating binding sites.
Tom van Schaik, Stefano Giustino Manzo, Athanasios E Vouzas…·Bas van Steensel
The paper investigates Ki67's role in chromatin organization by analyzing its genomic interactions and dynamics during the cell cycle in human cells.
Anna G. Manjón, Simon Linder, Hans Teunissen…·René H. Medema
This study reports that lentiviral-based CRISPR-Cas9 vectors can integrate into the target genomic location, unexpectedly activating the target gene.
Robin H. van der Weide, Teun van den Brand, Judith H.I. Haarhuis…·Elzo de Wit
GENOVA is an R-package for analysing Hi-C data, demonstrating that cohesin subunits SA1 and SA2 differentially affect loop formation and genome compartmentalisation.
Ning Qing Liu, Michela Maresca, Teun van den Brand…·Elzo de Wit
This study shows WAPL maintains dynamic cohesin at lineage-specific regulatory regions in mouse embryonic stem cells, which is essential for gene expression and pluripotency.
Ahmed M.O. Elbatsh, Eugene Kim, Jorine M. Eeftens…·Benjamin D. Rowland
This study shows that condensin complexes use opposing ATPase sites to drive and dampen chromosome condensation, with condensin II playing a key role in decatenation and axis formation.
Joris van Arensbergen, Ludo Pagie, Vincent FitzPatrick…·Bas van Steensel
The paper identifies over 30,000 SNPs affecting regulatory element activity using SuRE reporter technology, linking them to gene regulation and potential human traits.
Amin Allahyar, Carlo Vermeulen, Britta A. M. Bouwman…·Wouter L. de Laat
The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.