Cancer BiologybioRxivPreprint
The bone marrow microenvironment of RAS pathway mutant B-ALL is enriched for immunosuppressive regulatory T cells
Mauricio Nicolás Ferrao Blanco, Bexultan Kazybay, Alicia Perzolli…·Hermann Josef Vormoor
This study identifies an immunosuppressive bone marrow microenvironment in RAS-mutant B-ALL, enriched for regulatory T cells, and suggests CTLA-4 blockade could enhance T-cell-engager efficacy.
DOI 10.64898/2026.03.17.712388