ImmunologyNature CommunicationsPeer-reviewed
Tyk2-mediated signaling promotes the development of autoreactive CD8+ CTLs and autoimmune type 1 diabetes
Keiichiro Mine, Seiho Nagafuchi, Satoru Akazawa…·Keizo Anzai
This study shows Tyk2 inhibition reduces autoimmune T1D in NOD mice by impairing CD8+ CTL development and {beta}-cell inflammation.
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