Cancer BiologybioRxivPreprint
Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers
Richard C. Centore, Luis M. M. Soares, Salih Topal…·Steven F. Bellon
This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.