Hongwu Yu

This paper introduces NeoAPP, a tool to identify tumor-specific transcript-derived neoantigens in PDAC, revealing a large neoantigen reservoir that could improve immunotherapy.

This paper identifies neoantigen-encoding tumor-specific transcripts (neoTSTs) in hepatocellular carcinoma, showing they are more abundant and immunogenic than mutation-derived neoantigens, and demonstrate therapeutic potential in preclinical models.

This paper develops a cap-independent mRNA vaccine platform that enhances antitumor immunity through intrinsic adjuvanticity and improved in vivo expression.

This paper identifies TEtrans, gene-independent transcripts from transposable elements in tumors, which act as oncogenes and neoantigens, expanding the role of TEs in cancer.

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.