Yifan Wen

This paper introduces NeoAPP, a tool to identify tumor-specific transcript-derived neoantigens in PDAC, revealing a large neoantigen reservoir that could improve immunotherapy.

This paper identifies neoantigen-encoding tumor-specific transcripts (neoTSTs) in hepatocellular carcinoma, showing they are more abundant and immunogenic than mutation-derived neoantigens, and demonstrate therapeutic potential in preclinical models.

This paper develops a cap-independent mRNA vaccine platform that enhances antitumor immunity through intrinsic adjuvanticity and improved in vivo expression.

This paper identifies TEtrans, gene-independent transcripts from transposable elements in tumors, which act as oncogenes and neoantigens, expanding the role of TEs in cancer.

This study identifies JWA as an aging-associated gene whose deficiency disrupts intestinal epithelial homeostasis and accelerates aging in mice through the Notch1/PPARγ/Stat5 axis.