Developmental reversion underlies resistance to immune checkpoint blockade in kidney cancer
Dig Vijay Kumar Yarlagadda, Zhenghan Wang, Hui Jiang, Lynda H. Vuong, Andrea López Sanmiguel, Ching-Yeuh Yang, Ritesh R. Kotecha, Ying‐Bei Chen, A. Ari Hakimi, Christina S. Leslie, Joan Massagué
This study identifies developmental reversion to embryonic nephrogenesis in kidney cancer cells as a mechanism of resistance to immune checkpoint inhibitors.
bioRxiv · Aug 6, 2026 · PreprintCancer Biology