Joan Massagué

This study identifies developmental reversion to embryonic nephrogenesis in kidney cancer cells as a mechanism of resistance to immune checkpoint inhibitors.

Xenium and single-nucleus profiling of 14 human pancreatic tumors shows invaded nerve neighborhoods enriched for classical cancer cells, myCAFs and lipid-handling macrophages but depleted of lymphocytes.

This paper develops antibody-drug conjugates targeting L1CAM to treat metastatic cancer, showing potent tumor control and extended survival in mouse models.

This study identifies an atypical EMT induced by TGF-β in lung adenocarcinoma metastatic progenitors that reduces biomechanical stiffness, enabling evasion of immune surveillance during dormancy.

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

The paper identifies L1CAM-driven planar cell polarity signaling as a mechanism promoting SOX2+ metastatic progenitors in lung adenocarcinoma.

This study shows how cancer cell stiffness, influenced by environmental rigidity, affects immune response and metastatic site selection in mice and patients.

This study shows that Rreb1 is essential for mouse embryonic development, regulating epithelial architecture and invasiveness during gastrulation.

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.