Author

I. Arechaga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Fernandez· 1 shared A. Politis· 1 shared B. Miroux· 1 shared D. Santamaria· 1 shared E. Molina· 1 shared E. Pyle· 1 shared G. Bretones· 1 shared I. Collinson· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Fernandez

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2 papers

Recent·Most cited

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

J. Leon, L. Garcia-Gutierrez, G. Bretones, E. Molina, I. Arechaga, J. C. R. Acosta, R. Blanco, A. Fernandez, L. Alonso, P. Sicinski, M. Barbacid, D. Santamaria

The paper shows Myc activates Cdk1 to phosphorylate p27 at Thr187, promoting its degradation and cell cycle progression, with Cdk1 inhibition causing synthetic lethality with Myc.

bioRxiv · Dec 16, 2018Cancer Biology

Specific cardiolipin-SecY interactions are required for proton-motive-force stimulation of protein secretion

R. A. Corey, E. Pyle, W. J. Allen, M. Casiraghi, B. Miroux, I. Arechaga, A. Politis, I. Collinson

This study identifies and validates two conserved cardiolipin binding sites on the SecA-SecYEG complex, showing their role in ATP and PMF-driven protein secretion.

bioRxiv · Dec 6, 2017Biophysics