Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).
Y. Frosi, S. Ng, Y.-C. Lin, S. Jiang, S. R. Ramlan, D. Lama, C. S. Verma, I. Asial, C. J. Brown
This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.
bioRxiv · Feb 17, 2022Biochemistry