Author

Y. Frosi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

C. J. Brown· 3 shared C. S. Verma· 3 shared S. Kannan· 2 shared S. Ng· 2 shared S. R. Ramlan· 2 shared A. Chandramohan· 1 shared A. Partridge· 1 shared A. Sadruddin· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

C. J. Brown

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Author profile →

3 papers

Recent·Most cited

Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

C. Jelinska, S. Kannan, F. R. Winnerdy, Y. Frosi, S. R. Ramlan, R. Lakshminarayanan, C. J. Brown, A.-T. Phan, D. Rhodes, C. S. Verma

The paper designs and tests stapled peptides that inhibit DAXX, a protein involved in cancer, showing they enter cells and disrupt its interactions with other proteins.

bioRxiv · Sep 25, 2022Biochemistry

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

Y. Frosi, S. Ng, Y.-C. Lin, S. Jiang, S. R. Ramlan, D. Lama, C. S. Verma, I. Asial, C. J. Brown

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

bioRxiv · Feb 17, 2022Biochemistry

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

S. Kannan, P. G. A. Aronica, S. Ng, D. Thean, Y. Frosi, S. Chee, J. Shimin, T. Y. Yuen, A. Sadruddin, H. Y. K. Kaan, A. Chandramohan, J. H. Wong, Y. S. Tan, F. J. Ferrer, P. Arumugam, , A. Partridge

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

bioRxiv · Sep 12, 2019 · PreprintBiochemistry