Author

D. Lama

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:protein folding & dynamics· 4 Research Focus:cell signaling & trafficking· 3 Assay:protein structure· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:protein sequence· 2

Frequent Co-Authors

C. S. Verma· 3 shared C. Sahin· 3 shared D. P. Lane· 3 shared M. Landreh· 3 shared A. Rising· 2 shared C. J. Brown· 2 shared G. Chen· 2 shared G. V. Gese· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

C. S. Verma

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Adrenergic Reprogramming of Preexisting Adipogenic Trajectories Steer Naive Mural Cells Toward Beige Differentiation

D. Kathleen, B. N. Cortez, J. Z. Lin, D. Lama, M. D. Layne, S. R. Farmer, N. Rabhi

The paper shows that cold or β3-adrenoceptor activation reprograms adipogenic trajectories in vascular mural cells to generate beige adipocytes through Adrb3 and Adrb1 activation.

bioRxiv · Aug 26, 2023 · PreprintCell Biology

A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1

M. Saluri, A. Leppert, G. V. Gese, C. Sahin, D. Lama, M. Kaldmae, G. Chen, A. Elofsson, T. M. Allison, M. Arsenian-Henriksson, D. P. Lane, J. Johansson, B. M. Hallberg, M. Landreh

The paper investigates how NPM1 self-assembly and chaperone activity interact, finding that oligomerization modulates its ability to prevent amyloid formation.

bioRxiv · Sep 29, 2022 · PreprintBiophysics

Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures

C. Sahin, A. Motso, X. Gu, H. Feyrer, D. Lama, T. Arndt, A. Rising, G. V. Gese, B. M. Hällberg, E. G. Marklund, N. P. Schafer, K. Petzold, K. Teilum, P. G. Wolynes, M. Landreh

The paper uses mass spectrometry and simulations to study phase separation of RNA-binding proteins, revealing distinct assembly mechanisms and droplet structures.

bioRxiv · Sep 28, 2022Biophysics

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

Y. Frosi, S. Ng, Y.-C. Lin, S. Jiang, S. R. Ramlan, D. Lama, C. S. Verma, I. Asial, C. J. Brown

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

bioRxiv · Feb 17, 2022Biochemistry

A spindle and thread-mechanism unblocks translation of N-terminally disordered proteins

M. Kaldmae, T. Vosselman, X. Zhong, D. Lama, G. Chen, M. Saluri, N. Kronqvist, J. W. Siau, A. S. Ng, F. J. Ghadessy, P. Sabatier, B. Vojtesek, M. Sarr, C. Sahin, N. Osterlund, , M. Landreh

This study shows that fusing disordered proteins to an engineered spider silk domain improves their translation efficiency and activity in cells.

bioRxiv · Feb 22, 2021 · PreprintBiochemistry

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

P. V. Iyengar, D. L. Marvin, D. Lama, T. Z. Tan, S. Suriyamurthy, F. Xie, M. van Dinther, H. Mei, C. S. Verma, L. Zhang, L. Ritsma, P. ten Dijke

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

bioRxiv · Oct 12, 2020 · PreprintCancer Biology

Conformational ordering of intrinsically disordered peptides for targeting translation initiation

C. J. Brown, C. S. Verma, D. P. Lane, D. Lama

The paper develops bioactive peptides that modulate eIF4E binding by inducing conformational order in intrinsically disordered regions of eIF4G.

bioRxiv · Aug 20, 2020Biophysics

Phosphorylation regulates auto-inhibition of kinesin KIF3A

K. Chen, W.-G. Saw, D. Lama, C. Verma, G. Gruber, C.-G. Koh

This study identifies phosphorylation of serine-689/690 in KIF3A as critical for relieving auto-inhibition through conformational changes in the motor-tail interaction.

bioRxiv · Dec 21, 2018 · PreprintBiochemistry