Author

I. Bernstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. B. Abildgaard· 1 shared A. Shrikhande· 1 shared A. Stein· 1 shared A.-M. Gerdes· 1 shared B. Freie· 1 shared B. J. Varnum-Finney· 1 shared B. K. Hadland· 1 shared C. Ishioka· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. B. Abildgaard

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies

B. Freie, P. A. Carroll, B. J. Varnum-Finney, V. Ramani, I. Bernstein, R. N. Eisenman

This study shows a single point mutation in Myc leads to hematopoietic malignancies by altering MYC function in progenitor cells.

bioRxiv · Oct 23, 2023Cancer Biology

Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy

S. Kaonis, J. L. Smith, N. Katiyar, M. Merrill, T. Hylkema, S. Namciu, Q. Le, E. Babaeva, T. Ikeda, S. M. Morris, E. Girard, S. Furuyama, R. Ries, I. Bernstein, S. Meshinchi, , J. F. Sarthy

This study identifies BRG1 inhibition as a therapeutic strategy for CBFA2T3-GLIS2 AML by analyzing chromatin profiles and CRISPR dependencies.

bioRxiv · Aug 30, 2023 · PreprintCancer Biology

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

A. B. Abildgaard, A. Stein, S. V. Nielsen, K. Schultz-Knudsen, E. Papaleo, A. Shrikhande, E. R. Hoffmann, I. Bernstein, A.-M. Gerdes, M. Takahashi, C. Ishioka, K. Lindorff-Larsen, R. Hartmann-Petersen

The paper identifies structural destabilization and degradation of MLH1 variants in Lynch syndrome, linking reduced cellular levels to loss-of-function and suggesting stability predictions for diagnostic use.

bioRxiv · Oct 13, 2019Biochemistry