Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy
S. Kaonis, J. L. Smith, N. Katiyar, M. Merrill, T. Hylkema, S. Namciu, Q. Le, E. Babaeva, T. Ikeda, S. M. Morris, E. Girard, S. Furuyama, R. Ries, I. Bernstein, S. Meshinchi, , J. F. Sarthy
This study identifies BRG1 inhibition as a therapeutic strategy for CBFA2T3-GLIS2 AML by analyzing chromatin profiles and CRISPR dependencies.
bioRxiv · Aug 30, 2023 · PreprintCancer Biology