Author

I. Brandsma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Ashworth· 1 shared A. Drean· 1 shared A. Swain· 1 shared C. A. Mein· 1 shared C. J. Lord· 1 shared D. B. Krastev· 1 shared D. Mandrioli· 1 shared E. Bourne· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Ashworth

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Comparative toxicogenomics of glyphosate and Roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in Sprague-Dawley rats

R. Mesnage, M. Ibragim, D. Mandrioli, L. Falcioni, E. Tibaldi, F. Belpoggi, I. Brandsma, E. Bourne, E. Savage, C. A. Mein, M. N. Antoniou

This study compares the genotoxicity of glyphosate and Roundup herbicides using stem cell assays and molecular profiling in rats, finding Roundup causes more carcinogenesis-related changes.

bioRxiv · Apr 12, 2021Pharmacology & Toxicology

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

S. J. Pettitt, D. B. Krastev, I. Brandsma, A. Drean, F. Song, R. Aleksandrov, M. I. Harrell, M. Menon, R. Brough, J. Campbell, J. Frankum, M. Ranes, H. N. Pemberton, R. Rafiq, K. Fenwick, , C. J. Lord

The paper identifies PARP1 point mutations causing PARP inhibitor resistance through CRISPR-Cas9 screens and shows their impact on PARP1 trapping and chemotherapy sensitivity.

bioRxiv · Oct 14, 2017Cancer Biology