F. Song

Global invasion history and genomic signatures of adaptation of a highly invasive lace bug

This study investigates the genomic basis of invasion in the sycamore lace bug, identifying adaptation signatures and invasion routes through genomic analysis.

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

This study shows that PSMC3IP and MND1 depletion increases PARP inhibitor sensitivity in mitotic cells through impaired D-loop formation and homology-directed repair.

Meta-analysis of fecal metagenomes reveals global viral signatures and its diagnostic potential for colorectal cancer and adenoma

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.

A Modular Chemoenzymatic Approach to C14-Functionalized Steroids

This paper develops a modular chemoenzymatic method to synthesize diverse C14-functionalized steroids using a novel CYP14A enzyme and its variants.

Using Mathematical Modeling to Distinguish Intrinsic and Acquired Targeted Therapeutic Resistance in Head and Neck Cancer

This study uses mathematical models to determine the timing and mechanism of cetuximab resistance in HNSCC using tumor volume data from xenografts.

A simple, cost-effective and automation-friendly direct PCR approach for bacterial community analysis

This paper introduces a direct PCR method for bacterial community analysis that is cheaper, faster, and more scalable than traditional DNA extraction methods.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

Lipid Droplet Is an Ancient and Inheritable Organelle in Bacteria

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

SARS-COV-2 RBD Oral Vaccine Boosted by Mucosal Immune Adjuvant LTB26 via DCs and B Cells Activation in Mice

This paper develops an oral SARS-COV-2 RBD vaccine using LTB26 adjuvant in mice, showing enhanced antibody production and immune activation through DCs and B cells.

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

The paper identifies PARP1 point mutations causing PARP inhibitor resistance through CRISPR-Cas9 screens and shows their impact on PARP1 trapping and chemotherapy sensitivity.