R. Mesnage

Leukemia in Sprague-Dawley Rats Exposed Long-term from Prenatal Life to Glyphosate and Glyphosate-Based Herbicides

This study shows that glyphosate and glyphosate-based herbicides caused increased leukemia incidence in rats at exposure levels within the EU ADI and NOAEL.

Alterations in human gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME(R) technology

This study examines the effects of glyphosate and Roundup on the human gut microbiome using SHIME technology, finding increased fermentation and altered short-chain fatty acid levels.

Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome

This study shows that glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal communities in rat caecum microbiomes, with formulations causing more pronounced changes than glyphosate alone.

Cytotoxicity mechanisms and composition of the glyphosate formulated herbicide RangerPro

The paper tests the cytotoxicity of RangerPro, a glyphosate-based herbicide, and identifies POE-15 tallow amine as a toxic component in human intestinal cells.

Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

This study links pesticide exposure to changes in gut microbiome composition and function in adult twins using urinary biomarkers and metagenomic/metabolomic analyses.

Comparative toxicogenomics of glyphosate and Roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in Sprague-Dawley rats

This study compares the genotoxicity of glyphosate and Roundup herbicides using stem cell assays and molecular profiling in rats, finding Roundup causes more carcinogenesis-related changes.

Multi-omics phenotyping of the gut-liver axis allows health risk predictability from in vivo subchronic toxicity tests of a low-dose pesticide mixture

The paper uses multi-omics analysis on pesticide-exposed rats to show metabolic and epigenetic changes in the gut-liver axis that predict health risks not detected by standard tests.

Shotgun metagenomics and metabolomics reveal glyphosate alters the gut microbiome of Sprague-Dawley rats by inhibiting the shikimate pathway

This study shows glyphosate inhibits the shikimate pathway in rat gut microbiota, altering microbial communities and metabolites, with potential health implications.

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126

This study uses transcriptomics and metabolomics to show PCB 126 exposure disrupts lipid metabolism in HepaRG cells, causing oxidative stress and altered metabolite levels.

Transcriptome profiling reveals bisphenol A alternatives activate estrogen receptor alpha in human breast cancer cells

This study compares the estrogenic activity of bisphenol alternatives to BPA in breast cancer cells, finding some are more potent ER agonists.