W. Tempel

A small-molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

The paper identifies small molecule antagonists targeting the USP5 ZnF-UBD, providing a framework for developing chemical probes to study its role in ubiquitin signaling.

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain

This study investigates how MeCP2 recognizes unmethylated 5-CAC/GTG-3 DNA motifs through binding and structural analysis, revealing its adaptability and potential role in transcription activation and Rett syndrome.

Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function

This study compares the ATPase mechanisms and microtubule interactions of NOD and KID chromokinesins, revealing distinct structural and biochemical pathways for similar functions during cell division.

The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.