H. Ouyang

Bio-inspired mineralization collagen induce fibrocartilage regeneration after tendon-bone injury by activating Gli1+Dkk3+ progenitor cells

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

Gas tunnel engineering of prolyl hydroxylasereprograms hypoxia signaling in cells

This study reprograms hypoxia signaling by engineering PHD2 to enhance its catalytic efficiency, leading to reduced HIF-1 and hypoxia response transcripts under low oxygen conditions.

p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor suppressor function mediated by p190A RhoGAP

This study identifies RasGAP and ZO-2 as essential for p190A RhoGAP's tumor suppressor function and Hippo signaling activation.

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development

This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

Eurycomanone regulates lipid metabolism by activating the cAMP/PKA pathway

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

Introduction of the Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei leads to abnormal polarity and improves the ligno-cellulose degradation

This study introduces Aspergillus fumigatus α-1,2-mannosidase MsdS into Trichoderma reesei, altering N-glycan processing and improving lignocellulose degradation while causing abnormal polarity and secretion phenotypes.

AfRip3, a RIP3-like kinase, is identified as a key modulator of necroptotic death in Aspergillus fumigatus

This study identifies AfRip3 as a key modulator of necroptotic death in A. fumigatus, showing it is induced by Ca2+ and activates JNK and SMase pathways.

Widespread arginine phosphorylation in human cells - a novel protein PTM revealed by mass spectrometry

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells

The paper uses super-resolution imaging to reveal a novel hybrid cilium in airway multiciliated cells and its role as a signaling center.

High resolution profile of body wide pathological changes induced by abnormal elastin metabolism in Loxl1 knockout mice

This study uses a new method to profile body-wide transcriptomic changes in Loxl1 knockout mice, revealing systemic immune and proliferative alterations linked to elastin dysfunction and cancer.

Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors

The paper identifies HDAC6 ZnF-UBD inhibitors and describes their structure-activity relationships, revealing key binding features and potential for further optimization.