Cancer BiologybioRxiv
SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment
E. Gomez-Abenza, S. Ibanez-Molero, D. Garcia-Moreno…·V. Mulero
The paper shows Spint1a deficiency in zebrafish promotes SKCM aggressiveness by enhancing oncogenic transformation, regulating tumor-immune crosstalk, and accelerating metastasis.
DOI 10.1186/s13046-019-1389-3