BiochemistrybioRxiv
A generative algorithm for de novo design of proteins with diverse pocket structures
B. Basanta, M. J. Bick, A. K. Bera…·D. Baker
This paper introduces a generative algorithm for designing de novo proteins with diverse small molecule binding pockets, validated through experimental testing and showing improved stability and diversity compared to natural proteins.
DOI 10.1073/pnas.2005412117