Author

B. Basanta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

G. C. Lander· 2 shared A. F. Clouser· 1 shared A. K. Bera· 1 shared A. Maker· 1 shared A. Nath· 1 shared B. C. Lee· 1 shared B. J. Courteau· 1 shared C. M. Chow· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

G. C. Lander

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Author profile →

4 papers

Recent·Most cited

High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.

L. M. Chan, B. J. Courteau, A. Maker, M. Wu, B. Basanta, H. Mehmood, D. Bulkley, D. Joyce, B. C. Lee, S. Mick, S. Gulati, G. C. Lander, K. A. Verba

This study evaluates the Gatan Alpine detector at 100-200 keV for cryo-EM, showing improved resolution and performance compared to the Gatan K3.

bioRxiv · Feb 14, 2024Biophysics

A case for glycerol as an acceptable additive to cryoEM samples

B. Basanta, M. Hirschi, D. A. Grotjahn, G. C. Lander

This study shows glycerol can be used as a cryoEM sample additive without compromising high-resolution structure determination, using mouse apoferritin and rabbit muscle aldolase as examples.

bioRxiv · Sep 10, 2021Biophysics

A generative algorithm for de novo design of proteins with diverse pocket structures

B. Basanta, M. J. Bick, A. K. Bera, C. Norn, C. M. Chow, L. P. Carter, I. Goreshnick, F. Dimaio, D. Baker

This paper introduces a generative algorithm for designing de novo proteins with diverse small molecule binding pockets, validated through experimental testing and showing improved stability and diversity compared to natural proteins.

bioRxiv · Mar 23, 2020Biochemistry

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of \"quasi-ordered\" states.

A. F. Clouser, H. E. Baughman, B. Basanta, M. Guttman, A. Nath, R. E. Klevit

This study characterizes the disordered N-terminal region of HSPB1 using hybrid methods, revealing quasi-ordered states and their role in HSPB1 function and disease.

bioRxiv · Aug 29, 2019Biochemistry