Author

M. J. Bick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1

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Research Focus:protein design· 4 Approach:experimental assay· 3 Assay:protein structure· 3 Approach:deep learning· 2 Research Focus:protein structure prediction· 2 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Baker· 4 shared A. K. Bera· 3 shared A. Kang· 2 shared C. M. Chow· 2 shared L. P. Carter· 2 shared T. Brunette· 2 shared A. C. McShan· 1 shared A. Courbet· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiochemistry

D. Baker

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4 papers

Recent·Most cited

Precisely patterned nanofibers made from extendable protein multiplexes

N. P. Bethel, A. J. Borst, F. Parmeggiani, M. J. Bick, T. Brunette, H. Nguyen, A. Kang, A. K. Bera, L. Carter, M. C. Miranda, R. Kibler, M. Lamb, X. Li, B. Sankaran, D. Baker

The paper designs extendable protein multiplexes with symmetric architectures to create precisely patterned nanofibers through controlled repeat propagation and hydrophilic patch placement.

bioRxiv · Oct 14, 2022 · PreprintBioengineering

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Y. Hsia, R. Mout, W. Sheffler, N. I. Edman, I. Vulovic, Y.-J. Park, R. L. Redler, M. J. Bick, A. K. Bera, A. Courbet, A. Kang, T. Brunette, U. Nattermann, E. Tsai, A. Saleem, , D. Baker

This paper describes a hierarchical method to design multi-scale symmetric protein complexes using repeat proteins and helical bundles, resulting in large symmetric assemblies like an icosahedral nanocage.

bioRxiv · Jul 27, 2020Biochemistry

A generative algorithm for de novo design of proteins with diverse pocket structures

B. Basanta, M. J. Bick, A. K. Bera, C. Norn, C. M. Chow, L. P. Carter, I. Goreshnick, F. Dimaio, D. Baker

This paper introduces a generative algorithm for designing de novo proteins with diverse small molecule binding pockets, validated through experimental testing and showing improved stability and diversity compared to natural proteins.

bioRxiv · Mar 23, 2020Biochemistry

Computational design of a protein family that adopts two well-defined and structurally divergent de novo folds

K. Y. Wei, D. Moschidi, M. J. Bick, S. Nerli, A. C. McShan, L. P. Carter, P.-S. Huang, D. A. Fletcher, N. G. Sgourakis, S. E. Boyken, D. Baker

This paper designs a protein family with two structurally divergent folds, showing that sequences can adopt distinct conformations under different conditions.

bioRxiv · Sep 4, 2019 · PreprintBiochemistry