Biophysics of microRNA-34a targeting and its influence on down-regulation
L. Sweetapple, D. Kosek, E. Banijamali, W. Becker, J. Mueller, C. Karadiakos, L. Baronti, I. Guzzetti, D. Schritt, A. Chen, E. R. Andersson, K. Petzold
This study investigates how miR-34a interacts with its mRNA targets and how AGO2 modulates their binding affinity and structure, revealing structural determinants of repression efficacy.
bioRxiv · Feb 14, 2024Biophysics