J. Mueller

Ancient environmental DNA reveals the distinct fingerprints of whaling and climate change on Antarctic marine biodiversity

This study uses ancient environmental DNA to show how whaling and climate change impacted Antarctic marine biodiversity over two centuries.

An adapted typology of tree-related microhabitats including tropical forests

This study extends the typology of tree-related microhabitats to include tropical forests and compares their diversity between tropical and temperate forests.

Phaeocystis blooms caused carbon drawdown during the Antarctic Cold Reversal from sedimentary ancient DNA

This study uses ancient DNA analysis to show that Phaeocystis blooms contributed to carbon drawdown during the Antarctic Cold Reversal, linking sea-ice changes to productivity shifts.

Dynamic land-plant carbon sources in marine sediments inferred from ancient DNA

This study uses ancient DNA from marine sediments to infer dynamic land-plant carbon sources during the Last Glacial-Holocene transition, revealing vegetation dynamics and translocation patterns.

Biophysics of microRNA-34a targeting and its influence on down-regulation

This study investigates how miR-34a interacts with its mRNA targets and how AGO2 modulates their binding affinity and structure, revealing structural determinants of repression efficacy.

Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties

This study investigates how glioblastoma cells use hyaluronan to support proliferation and resistance, proposing a combination treatment targeting HA synthesis and degradation.

Transient septin sumoylation steers a Fir1-Skt5 protein complex between the split septin ring

The paper investigates how septin sumoylation directs the movement of the Fir1-Skt5 complex during yeast cell separation.

Plant infection by the necrotrophic fungus Botrytis requires actin-dependent generation of high invasive turgor pressure

This study shows Botrytis uses actin-dependent invasive pressure and surface adherence to penetrate plant cells, reducing virulence when actin polymerization is blocked.

Isolation and quantification of bacterial membrane vesicles for quantitative metabolic studies using mammalian cell cultures

This study introduces a method to quantify bacterial membrane vesicles using FM4-64 dye and linear regression, showing its superiority over protein-based methods and identifying a key regulator in vesicle-mediated pathogenesis.

The Plasmodium falciparum CCCH zinc finger protein MD3 regulates male gametocytogenesis through its interaction with RNA-binding proteins

A fast-slow trait continuum at the level of entire communities

The paper shows that slow and fast functional strategies manifest at the ecosystem level, driven by disturbance and resource availability in grassland communities.

Upscaling biodiversity monitoring: Metabarcoding estimates 31,846 insect species from Malaise traps across Germany

The paper demonstrates a cost-effective DNA metabarcoding workflow for large-scale insect biodiversity monitoring, estimating 31,846 species from Malaise trap samples across Germany.

Endoplasmic reticulum calnexins participate in the primary root growth response to phosphate deficiency

This study shows that calnexin, an ER lectin chaperone, is involved in primary root growth under phosphate deficiency by regulating Fe-dependent processes.

Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

This study identifies cyclin B3 as essential for maintaining meiosis I arrest in oocytes by regulating Emi2 degradation, ensuring timely meiosis II arrest for fertilization.

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

Partitioning of ribonucleoprotein complexes from the cellular actin cortex

The paper introduces a fluorescence microscopy method to study the spatial distribution of RNA-binding proteins and finds they are excluded from the actin cortex due to their size.

The viral vectored vaccine targeting Thymosin β10 controls tumour growth in a murine model of prostate cancer

This study uses immunopeptidomic analysis to identify peptides overexpressed in murine prostate cancer and evaluates a viral vectored vaccine targeting Thymosin β10 for tumour growth control in a TRAMP model.

Disentangling effects of climate and land use on biodiversity and ecosystem services - a multi-scale experimental design

This paper introduces a multi-scale experimental design to study the effects of climate and land use on biodiversity and ecosystem services, achieving low correlations between environmental variables across scales.

SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy

This study shows that SARS-CoV-2 infection reduces KLF2 in human lung autopsies, linking KLF2 down-regulation to vascular dysfunction in ARDS.

The secreted hypersensitive response inducing protein 1 from Botrytis cinerea displays non-canonical PAMP-activity

The paper identifies and characterizes Hip1, a protein from Botrytis cinerea that induces plant cell death through non-canonical PAMP activity.

Cellular Protrusions Engage Viral Infection Enhancing EF-C Peptide Nanofibrils

This study shows that peptide nanofibrils enhance viral infection by being actively engaged by cellular protrusions, not through random binding.

Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice.

This study evaluates the effects of 15 bumped kinase inhibitors on zebrafish embryo development and mouse pregnancy, finding limited predictive value of zebrafish tests for pregnancy outcomes.

The Zinc Finger Antiviral Protein restricts SARS-CoV-2

This paper identifies ZAP as an IFN-induced antiviral effector that restricts SARS-CoV-2 by targeting CpG dinucleotides, though SARS-CoV-2 may be adapted to low CpG environments.

Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

This study shows that Ena/VASP proteins promote cell migration by regulating lamellipodium architecture, actin dynamics, and integrin-dependent adhesion.

Neolithic genomes reveal a distinct ancient HLA allele pool and population transformation in Europe

The paper analyzes Neolithic genomes from Germany to show genetic heterogeneity and a high hunter-gatherer ancestry component in a WBC population, with distinct HLA allele pools related to viral immunity.

Antibody Complementarity Determining Region Design Using High-Capacity Machine Learning

This paper introduces a machine learning method to design human IgG antibodies with superior target affinity and specificity, using high-throughput data without requiring target structural information.

Abiotic environmental adaptation in vertebrates is characterized by functional genomic constraint

The paper identifies genes involved in abiotic environmental adaptation across vertebrates and finds evidence of functional genomic constraint and recurrent gene use.

Identifying hetero-protein complexes in the nuclear envelope

This paper introduces dual-color tsMSQ to identify hetero-protein complexes in the nuclear envelope and demonstrates its application to the LINC complex.

Core components of endosomal mRNA transport are evolutionarily conserved in fungi

The paper identifies conserved core components of endosomal mRNA transport in fungi, showing that these components are present across distantly related fungal phyla.