Author

K. Petzold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. Feyrer· 2 shared I. Guzzetti· 2 shared J. Schlagnitweit· 2 shared W. Becker· 2 shared A. Chen· 1 shared A. J. Pell· 1 shared A. Jaworski· 1 shared A. Motso· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

H. Feyrer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Elucidating microRNA-34a organisation within Human Argonaute-2 by DNP MAS NMR

R. Dasgupta, W. Becker, K. Petzold

The paper uses DNP MAS NMR to study the structural organization of miR-34a in hAgo2 and its interaction with SIRT1 mRNA, revealing conformational changes and dynamic states.

bioRxiv · Mar 28, 2024Biochemistry

Biophysics of microRNA-34a targeting and its influence on down-regulation

L. Sweetapple, D. Kosek, E. Banijamali, W. Becker, J. Mueller, C. Karadiakos, L. Baronti, I. Guzzetti, D. Schritt, A. Chen, E. R. Andersson, K. Petzold

This study investigates how miR-34a interacts with its mRNA targets and how AGO2 modulates their binding affinity and structure, revealing structural determinants of repression efficacy.

bioRxiv · Feb 14, 2024Biophysics

Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures

C. Sahin, A. Motso, X. Gu, H. Feyrer, D. Lama, T. Arndt, A. Rising, G. V. Gese, B. M. Hällberg, E. G. Marklund, N. P. Schafer, K. Petzold, K. Teilum, P. G. Wolynes, M. Landreh

The paper uses mass spectrometry and simulations to study phase separation of RNA-binding proteins, revealing distinct assembly mechanisms and droplet structures.

bioRxiv · Sep 28, 2022Biophysics

Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model

L. Graetz, J. J. Sajkowska-Kozielewicz, J. Wesslowski, K. Petzold, G. Davidson, G. Schulte, P. Kozielewicz

The paper assesses WNT-3A binding affinity to endogenous versus overexpressed FZD7 in colorectal cancer cells and finds lower affinity with higher receptor concentrations.

bioRxiv · Jul 4, 2022Pharmacology & Toxicology

Purely enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR

H. Feyrer, C. O. Gurdap, M. Marusic, J. Schlagnitweit, K. Petzold

This study develops an enzymatic method to label RNA with isotopes for NMR analysis, revealing conformational exchange through hidden peaks.

bioRxiv · Feb 16, 2022Biochemistry

Observing an antisense drug complex in intact human cells by in-cell NMR

J. Schlagnitweit, S. F. Sandoz, A. Jaworski, I. Guzzetti, F. Aussenac, R. J. Carbajo, E. Chiarparin, A. J. Pell, K. Petzold

This study uses in-cell NMR to observe an antisense drug complex in intact human cells, confirming its activity and overcoming limitations of traditional methods.

bioRxiv · Mar 27, 2019Biophysics