Cancer BiologybioRxiv
Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids
J. F. Dekkers, M. Alieva, A. Cleven…·A. C. Rios
The paper develops BEHAV3D, a 3D imaging-transcriptomics platform to study T cell behavior and molecular mechanisms in cancer organoids, identifying a super engager cluster with unique gene signatures and IFN-I priming capabilities.
DOI 10.1038/s41587-022-01397-w