Author

I. K. Gaszek

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Evolutionary Biology· 1

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Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. R. Atilgan· 1 shared C. Atilgan· 1 shared E. Toprak· 1 shared H. Abdizadeh· 1 shared K. Reynolds· 1 shared T. Batur· 1 shared Y. T. Tamer· 1 shared

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2018-2018 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

A. R. Atilgan

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1 paper

Recent·Most cited

Evolutionary BiologybioRxivAug 22, 2018

High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection

Y. T. Tamer, I. K. Gaszek, H. Abdizadeh…·E. Toprak

The paper quantifies high-order epistasis in DHFR mutations under trimethoprim selection, revealing complex fitness landscapes and implications for inhibitor design.

DOI 10.1093/molbev/msz086

E. coliproteomics

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