Author

I. Kass

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. M. Buckle· 4 shared B. T. Riley· 3 shared N. A. Borg· 3 shared B. T. Porebski· 2 shared J. Fodor· 2 shared S. McGowan· 2 shared A. Woolfson· 1 shared B. K. Hayes· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersBiochemistry

A. M. Buckle

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity

M. Fellner, R. Parakra, K. O. McDonald, I. Kass, G. N. L. Jameson, S. M. Wilbanks, E. C. Ledgerwood

The paper investigates how pathogenic cytochrome c variants alter structure and dynamics, linking these changes to increased apoptotic activity and peroxidase function.

bioRxiv · Jun 14, 2020Biochemistry

The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome

J. Fodor, B. T. Riley, I. Kass, A. M. Buckle, N. A. Borg

This study uses molecular dynamics to show abacavir alters peptide conformations bound to HLA-B*57:01, influencing immune self-reactivity and hypersensitivity.

bioRxiv · Feb 27, 2019Immunology

A metal-dependent switch moderates activity of the hexameric M17 aminopeptidases.

N. Drinkwater, W. Yang, B. T. Riley, B. K. Hayes, K. Kannan Sivaraman, T. R. Malcolm, S. C. Atkinson, N. A. Borg, I. Kass, A. M. Buckle, S. McGowan

This study identifies a metal-dependent regulatory mechanism in PfA-M17 aminopeptidase, showing how oligomerization and metal center re-modelling control proteolytic activity.

bioRxiv · Feb 21, 2019 · PreprintBiochemistry

Reactive Centre Loop Dynamics and Serpin Specificity

E. M. Marijanovic, J. Fodor, B. T. Riley, B. T. Porebski, M. G. Costa, I. Kass, D. E. Hoke, S. McGowan, A. M. Buckle

This study investigates serpin specificity by engineering the reactive centre loop (RCL) of a synthetic serpin, finding that RCL sequence alone does not determine specificity, and that local electrostatics and dynamics also play critical roles.

bioRxiv · Aug 14, 2018Biochemistry

Structural Capacitance in Protein Evolution and Human Diseases

C. Li, L. V. Clark, R. Zhang, B. T. Porebski, J. M. McCoey, N. A. Borg, G. I. Webb, I. Kass, M. Buckle, J. Song, A. Woolfson, A. M. Buckle

The paper identifies structural capacitance as a new mechanism in protein evolution that generates microstructure in disordered regions, linking it to disease and evolutionary adaptability.

bioRxiv · Feb 22, 2018Biochemistry