Author

D. E. Hoke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 5 Approach:experimental assay· 3 Organism:human· 3 Assay:structural biology· 3 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

A. M. Buckle· 4 shared B. T. Porebski· 3 shared B. T. Riley· 3 shared P. G. Chandler· 3 shared J. Fodor· 2 shared M. Buckle· 2 shared M. G. Costa· 2 shared S. McGowan· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiochemistry

A. M. Buckle

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Author profile →

5 papers

Recent·Most cited

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

S. Stander, C. F. Reboul, S. N. Lee, D. Williams, P. G. Chandler, M. G. Costa, D. E. Hoke, J. D. Jimma, J. Fodor, G. Fenalti, S. I. Mannering, B. T. Porebski, P. Schofield, D. Christ, M. Buckle, , A. M. Buckle

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

bioRxiv · Mar 18, 2024 · PreprintBiochemistry

Mutational and biophysical robustness in a pre-stabilized monobody

P. G. Chandler, L. L. Tan, B. T. Porebski, J. S. Green, B. T. Riley, S. S. Broendum, D. E. Hoke, R. J. Falconer, T. P. Munro, M. Buckle, C. J. Jackson, A. M. Buckle

This paper grafts binding loops from an Adnectin onto a pre-stabilized FN3Con scaffold to create a stable monobody that binds VEGFR2 with high affinity and long-term stability.

bioRxiv · Dec 14, 2020 · PreprintBiochemistry

Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease

D. E. Williams, S. N. Le, D. E. Hoke, P. G. Chandler, M. Gora, M. Godlewska, J. P. Banga, A. M. Buckle

This study characterizes the structural and biophysical properties of thyroid peroxidase constructs and shows how autoantibodies bind the monomeric form, revealing conformational changes in the epitope.

bioRxiv · Dec 15, 2019Biochemistry

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

B. T. Riley, O. Ilyichova, S. de Veer, J. swedberg, E. Wilson, D. E. Hoke, J. Harris, A. Buckle

This paper investigates how structural modifications in SFTI-based inhibitors affect their interaction with KLK4, revealing insights into protease inhibition dynamics.

bioRxiv · Mar 8, 2019Biochemistry

Reactive Centre Loop Dynamics and Serpin Specificity

E. M. Marijanovic, J. Fodor, B. T. Riley, B. T. Porebski, M. G. Costa, I. Kass, D. E. Hoke, S. McGowan, A. M. Buckle

This study investigates serpin specificity by engineering the reactive centre loop (RCL) of a synthetic serpin, finding that RCL sequence alone does not determine specificity, and that local electrostatics and dynamics also play critical roles.

bioRxiv · Aug 14, 2018Biochemistry