S. McGowan

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

Structure of a Rhs effector clade domain identifies new mechanistic insights into type VI secretion system toxin delivery.

The paper presents the structure of Tse15, a T6SS Rhs effector from Acinetobacter baumannii, revealing a novel mechanism for toxin delivery and activation involving auto-cleavage and domain interaction.

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

This study validates PfA-M17 as a novel drug target by showing its essential role in Plasmodium falciparum survival and demonstrating the efficacy of a specific inhibitor.

The component parts of bacteriophage virions accurately defined by a machine-learning approach built on evolutionary features.

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

Toxoplasma gondii Toxolysin 4 contributes to efficient parasite egress from host cells

This study identifies Toxolysin 4 (TLN4) as a metalloproteinase necessary for efficient Toxoplasma gondii egress from host cells.

Mapping the substrate sequence and length of the Plasmodium M1 and M17 aminopeptidases

This study profiles the substrate specificity and kinetic behavior of M1 and M17 aminopeptidases from Plasmodium species, revealing differences in substrate preference and catalytic responses across species.

Metal Dependent Dynamic Equilibrium: A Regulatory Mechanism for M17 Aminopeptidases from Plasmodium falciparum and Plasmodium vivax

This study identifies a metal-dependent dynamic equilibrium in M17 aminopeptidases from Plasmodium species that regulates hexamer formation and catalytic activity.

A metal-dependent switch moderates activity of the hexameric M17 aminopeptidases.

This study identifies a metal-dependent regulatory mechanism in PfA-M17 aminopeptidase, showing how oligomerization and metal center re-modelling control proteolytic activity.

Reactive Centre Loop Dynamics and Serpin Specificity

This study investigates serpin specificity by engineering the reactive centre loop (RCL) of a synthetic serpin, finding that RCL sequence alone does not determine specificity, and that local electrostatics and dynamics also play critical roles.