Author

M. Spahn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

M. Kruithof-de Julio· 3 shared M. R. De Filippo· 3 shared A. Sboner· 2 shared E. Zoni· 2 shared G. N. Thalmann· 2 shared I. Klima· 2 shared S. Karkampouna· 2 shared S. Piscuoglio· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

M. Kruithof-de Julio

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3 papers

Recent·Most cited

Patient-derived xenografts and organoids model therapy response in prostate cancer

S. Karkampouna, F. La Manna, M. R. De Filippo, M. Kiener, M. De Menna, E. Zoni, J. Grosjean, I. Klima, A. Garofoli, M. Bolis, J.-P. Theurillat, V. Genitsch, D. Keller, T. Booij, C. Stirnimann, , M. Kruithof-de Julio

This study develops a patient-derived xenograft (PDX) model of prostate cancer that mimics disease stages and identifies drug sensitivities in metastatic cases.

Nature Communications · Feb 18, 2021Peer-reviewedCancer Biology

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

J. Cyrta, A. Augspach, M. R. de Filippo, D. Prandi, P. Thienger, M. Benelli, V. Cooley, R. Bareja, D. Wilkes, S.-S. Chae, P. Cavaliere, N. Dephoure, A.-C. Uldry, S. B. Lagache, S. Cohen, , M. Rubin

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Nature Communications · Nov 3, 2020Peer-reviewedCancer Biology

Stroma transcriptomic and proteomic profile of prostate cancer metastasis xenograft models reveals conservation of bonemicroenvironment signatures

S. Karkampouna, M. R. De Filippo, C. Y. Ng, I. Klima, E. Zoni, M. Spahn, F. Stein, P. Haberkant, G. N. Thalmann, M. Kruithof-de Julio

The paper identifies tenascin C as a stromal marker associated with metastasis in prostate cancer xenograft models and shows its prognostic potential in patient samples.

bioRxiv · Apr 3, 2020Cancer Biology