Author

F. Demichelis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2

Frequent Co-Authors

D. Prandi· 2 shared H. Beltran· 2 shared M. Benelli· 2 shared M. Kruithof-de Julio· 2 shared P. Gasperini· 2 shared Y. Ciani· 2 shared A. Augspach· 1 shared A. Di Leo· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

D. Prandi

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6 papers

Recent·Most cited

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer

S. Lago, V. Poli, L. Fol, M. Botteon, A. Fasciani, A. Turdo, M. Gaggianesi, M. Todaro, Y. Ciani, G. D Amato, F. Demichelis, a. Zippo

The paper identifies ANP32E as a driver of vulnerability to ATR inhibitors in triple-negative breast cancer by promoting R-loop-dependent transcription replication conflicts and genomic instability.

bioRxiv · Mar 25, 2024Cancer Biology

Integrating extracellular vesicle and circulating cell-free DNA analysis on a single plasma aliquot from breast cancer patients improves the detection of HER2 positivity

V. Mugoni, Y. Ciani, O. Quaini, S. Tomasini, M. Notarangelo, F. Vannuccini, A. Marinelli, E. Leonardi, S. Pontalti, A. Martinelli, D. Rossetto, I. Pesce, S. S. Mansy, M. Barbareschi, A. Ferro, , F. Demichelis

This paper combines extracellular vesicle RNA and circulating cell-free DNA analysis from a single blood sample to improve HER2 positivity detection in breast cancer patients.

bioRxiv · Mar 2, 2023 · PreprintCancer Biology

Bladder cancer organoids as a functional system to model different disease stages and therapy response

M. Minoli, T. Cantore, M. Kiener, T. Fedrizzi, F. La Manna, S. Karkampouna, V. Genitisch, A. Rodriguez, I. Klima, P. Gasperini, B. Kiss, R. Seiler-Blarer, F. Demichelis, G. N. Thalmann, M. Kruithof-de Julio

This study uses bladder cancer patient-derived organoids to model disease stages and therapy response, identifying markers of resistance and sensitivity.

bioRxiv · Mar 31, 2022 · PreprintCancer Biology

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

J. Cyrta, A. Augspach, M. R. de Filippo, D. Prandi, P. Thienger, M. Benelli, V. Cooley, R. Bareja, D. Wilkes, S.-S. Chae, P. Cavaliere, N. Dephoure, A.-C. Uldry, S. B. Lagache, S. Cohen, , M. Rubin

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Nature Communications · Nov 3, 2020Peer-reviewedCancer Biology

Cancer methylomes characterization enabled by Rocker-meth

M. Benelli, G. M. Franceschini, A. Magi, D. Romagnoli, C. Biagioni, I. Migliaccio, L. Malorni, A. Di Leo, F. Demichelis

Rocker-meth detects DMRs across 6,000 methylation profiles from 14 tumor types, revealing tumor-specific and shared DMRs and linking DNA hypermethylation to transcription factor deregulation.

bioRxiv · Oct 9, 2020 · PreprintCancer Biology

Proteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal Tissues

E. Persi, D. Prandi, Y. I. Wolf, Y. Pozniak, C. Barbieri, P. Gasperini, H. Beltran, B. M. Faltas, M. A. Rubin, T. Geiger, E. V. Koonin, F. Demichelis, D. Horn

The paper quantifies repeat-instability in cancer and normal tissues using proteomic and genomic data, identifying tumor-specific signatures linked to progression and tumorigenic state.

bioRxiv · Dec 9, 2018Cancer Biology