I. Koyama-Honda

The paper determines the average shapes of forming autophagosomes using 3D electron microscopy and develops a model showing their morphology is determined by the ratio of rim size to surface area.

This study identifies SIDT2 as a mediator of microautophagy that delivers cytosolic proteins into lysosomes, linking proteostasis to protein aggregation disease.

High-speed single-molecule imaging shows outer-leaflet rafts induce transbilayer raft phases that recruit inner-leaflet signaling molecules via lipid interactions.