S. Takahashi

This paper introduces label-free ghost cytometry (LF-GC) for cell therapy manufacturing, showing it can quantify cell count, viability, and identify cell subsets and impurities without staining.

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

This study generates functional adult hearts in Mesp1/2-deficient mice using blastocyst complementation with pluripotent stem cells, showing successful derivation of all cardiovascular lineages from exogenous cells.

This study investigates the pathogenic effects of the p.R130S prestin variant in DFNB61 hearing loss, showing it causes progressive outer hair cell loss and reduced motor kinetics.

This study examines how river discharge affects microbial community structure and metabolic functions in hyporheic zones of gravel bars.

This study shows that Prdm13 signaling in the dorsomedial hypothalamus affects age-related sleep-wake changes in mice, and dietary restriction can mitigate these effects.

The paper determines the average shapes of forming autophagosomes using 3D electron microscopy and develops a model showing their morphology is determined by the ratio of rim size to surface area.

The paper shows that low pH triggers cellulase-mediated release of monosaccharides from algal cell walls in coral symbionts.

The paper profiles antibody responses to Plasmodium falciparum antigens in Ugandan cohorts, finding that repeat-containing antigens show stronger exposure-dependent responses and shared cross-reactive motifs.

This study shows that high glucose levels in urine promote Candida albicans growth and reduce susceptibility to azoles and 5-fluorocytosine.

The paper reconstitutes prenyltransferase activity using proteins from Para rubber tree and guayule in nanodiscs, showing that HRT1 and HRBP form an active complex.

This study shows that INT-767 prevents fibrosis in iPSC-derived renal organoids by modulating the TEAD4/TAZ pathway.

This study evaluates solvent use in microphysiological systems fabrication, showing that solvent bonding harms cell cultures while photobonding avoids these issues.

This study shows SAF-A promotes DNA replication by enhancing origin licensing and fork progression, preventing replication defects and cell quiescence.

This study identifies CEC3 as a conserved effector in Colletotrichum fungi that induces nuclear expansion and cell death in plants, supporting its role in the hemibiotrophic lifestyle.

This study determines the molecular mechanisms of two Diels-Alderases that produce enantiomeric decalin scaffolds through structural and computational analyses.

This study identifies the HBO1-MLL interaction as critical for leukemogenesis by facilitating the AF4/ENL/P-TEFb complex-mediated gene activation in MLL fusion proteins.

This study analyzes lncRNAs, 24-nt siRNAs, DNA methylation, and H3K27me3 in Brassica rapa and related species to understand their epigenetic interactions and conservation patterns.

This study shows HOXA9 promotes MYC-driven leukemogenesis by maintaining anti-apoptotic gene expression through multiple pathways.

The paper shows that P. verrucosa coral larvae use phototaxis to position themselves near the surface, while other species do not.

This study sequenced the genome of a kleptoplastic sea slug and found no evidence of algal gene transfer to the nucleus, showing photosynthesis can occur without nuclear gene transfer.

This study assesses how reservoir-derived plankton affect stream macroinvertebrates in different habitats, finding lower trophic contributions in lentic habitats compared to lotic ones.

This study identifies Cables2 as a Smad2-regulatory factor required for early embryonic development in mice, showing its role in gastrulation and gene expression patterns.

This study identifies a panel of cancer/testis antigens differentially expressed in metastatic prostate cancer, showing potential as biomarkers for diagnosis and immunotherapy targets.

This study identifies invadolysin, a conserved metalloprotease present in invertebrate hemolymph and vertebrate blood, suggesting a role in organismal physiology.

This study identifies ZMYND10 as a co-chaperone for FKBP8-HSP90 in axonemal dynein assembly, showing its role in ciliary motility and implications for PCD treatment.