Extracellular release of damaged mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates graft-versus-host disease
V. Vijayan, H. Yan, J. K. Lohmeyer, K. A. Prentiss, R. V. Patil, G. Barbarito, I. Lopez, A. Elezaby, K. Peterson, J. Baker, N. P. Ostberg, A. Bertaina, R. S. Negrin, D. Mochly-Rosen, K. Weinberg, B. Haileselassie
This study shows that conditioning before hematopoietic stem cell transplant releases damaged mitochondria, which activate host APCs and worsen GVHD.
bioRxiv · Apr 24, 2023 · PreprintImmunology